The emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) poses grave threats to human health.These strains increased dramatically in clinical settings in China in the past few years but not in other parts of the world.Four isogenic K.pneumoniae strains, including classical K.pneumoniae, carbapenem-resistant K.pneumoniae (
SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability
Abstract Innervation of the hypothalamic median eminence 7-Piece Power Reclining Sectional by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction.However, the molecular and cellular mechanisms underlying median eminence development and pubertal timing are incompletely understood.Here we show th
Potentiation of curing by a broad-host-range self-transmissible vector for displacing resistance plasmids to tackle AMR.
Plasmids are potent vehicles for spread of antibiotic resistance genes in bacterial populations and often persist in the absence of selection due to efficient maintenance mechanisms.We previously constructed non-conjugative high copy number plasmid vectors that efficiently displace stable plasmids from enteric bacteria in a laboratory context by bl
Role of self-sufficiency, productivity and diversification on the economic sustainability of farming systems with autochthonous sheep breeds in less favoured areas in Southern Europe
Traditional mixed livestock cereal- and pasture-based sheep farming systems in Europe are threatened by intensification and specialisation processes.However, the intensification process does not always yield improved economic results or efficiency.This study involved a group of farmers that raised an autochthonous sheep breed (Ojinegra de Teruel) i